Clinical Pharmacology with Nathan Teuscher

Hosted ByNathan Teuscher

This is Clinical Pharmacology podcast with Nathan Teuscher where I discuss clinical pharmacology and pharmacometrics topics from the perspective of drug development scientists.

11: Model diagnostics and selection (Ep. 11)

This episode is a discussion on model evaluation and selection. I discussed diagnostic plots using predictions and residuals. I covered approaches for model selection and factors to consider. The focus of this episode is on models that predict continuous endpoints like drug concentration, biomarkers, or other continuous endpoints. Several figures are mentioned in the podcast and links to those images can be found below.

Links discussed in the show:

  • Figure 1: Observed vs Predicted for single-subject model (example of a good model fit). Figure generated using ggplot in R.
  • Figure 2: Observed vs Predicted for single-subject model (example of a poor model fit) using logarithmic scales. Figure generated using ggplot in R.
  • Figure 3: Observed vs Population and Individual Predicted for population model. Figures generated using ggCertara package in R.
  • Figure 4: Weighted residuals versus time, time after dose, and population prediction for population model. Figures generated using ggCertara package in R.
  • You can connect with me on LinkedIn and send me a message
  • Do you need help with model selection? Send me a message
  • Sign up for my newsletter

Copyright Teuscher Solutions LLC

All Rights Reserved

Leave a Reply

Your email address will not be published. Required fields are marked *