Clinical Pharmacology Podcast
A podcast for drug development scientists where Nathan Teuscher gives concise explanations to your clinical pharmacology and pharmacometrics questions.
Latest episode
Inter-occasion variability and shrinkage in PK modeling (Ep. 61)
Today’s episode is about inter-occasion variability and η-shrinkage. Episodes 11, 36, 44, and 45 covered diagnostics, covariate search, estimation methods, and base-model selection. None of them…
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More recent episodes
See all 61 episodes →Exposure-Response modeling
Today’s episode is about exposure response modeling. What is ER analysis? When is it used? How do you do it? And what tools can be used for ER modeling? Links discussed in the show: ICH M15 Guideline…
Renal and Hepatic Impairment (Ep. 59)
Today’s episode is a discussion of renal and hepatic impairment. I review the biology of the kidney and liver and how we analyze pharmacokinetic data to assess their impact on drug exposure. Links…
Beyond Small Molecules—Allometric Scaling for Biologics and Engineered mAbs (Ep. 58)
Today’s episode is about allometric scaling with therapeutic antibodies. I discuss differences from small molecules, how to handle antibodies with engineered Fc regions (e.g. YTE or LS), and using…
Bioequivalence Testing: The Stats Behind Generic Drug Approvals (Ep. 57)
In this episode I discuss bioequivalence testing and how it was developed to support generic drug approvals, but is now a mainstream tool for all of drug development. I discuss the basics of what…
