Clinical Pharmacology Podcast
A podcast for drug development scientists where Nathan Teuscher gives concise explanations to your clinical pharmacology and pharmacometrics questions.
Latest episode
Exposure-Response modeling
Today’s episode is about exposure response modeling. What is ER analysis? When is it used? How do you do it? And what tools can be used for ER modeling? Links discussed in the show: ICH M15 Guideline…
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More recent episodes
See all 60 episodes →Renal and Hepatic Impairment (Ep. 59)
Today’s episode is a discussion of renal and hepatic impairment. I review the biology of the kidney and liver and how we analyze pharmacokinetic data to assess their impact on drug exposure. Links…
Beyond Small Molecules—Allometric Scaling for Biologics and Engineered mAbs (Ep. 58)
Today’s episode is about allometric scaling with therapeutic antibodies. I discuss differences from small molecules, how to handle antibodies with engineered Fc regions (e.g. YTE or LS), and using…
Bioequivalence Testing: The Stats Behind Generic Drug Approvals (Ep. 57)
In this episode I discuss bioequivalence testing and how it was developed to support generic drug approvals, but is now a mainstream tool for all of drug development. I discuss the basics of what…
Examining Volume of Distribution (Ep. 56)
In this episode we’re going to define Volume of Distribution, look at the different types of Volume of Distribution parameters, talk about how we actually calculate it, examine what drives its value,…
