Episode 58 · · 20 min
58: Beyond Small Molecules—Allometric Scaling for Biologics and Engineered mAbs (Ep. 58)
Today’s episode is about allometric scaling with therapeutic antibodies. I discuss differences from small molecules, how to handle antibodies with engineered Fc regions (e.g. YTE or LS), and using allometry to extrapolate from adults to pediatrics for these antibodies.
Links discussed in the show:
- Haray and Tachibana’s article on allometric exponents for monoclonal antibodies
- Exponents for standard antibodies: CL = 0.8, Q = 0.75, Vc = 1/.0, Vp = 0.95
- Exponents for modified antibodies: CL = 0.55, Q = 6, Vc = 0.95, Vp = 0.95
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