Episode 61 · October 26, 2026 · 23 min

61: Inter-occasion variability and shrinkage in PK modeling (Ep. 61)

Speed

Today’s episode is about inter-occasion variability and η-shrinkage. Episodes 11, 36, 44, and 45 covered diagnostics, covariate search, estimation methods, and base-model selection. None of them treated occasion variability or shrinkage in population PK modeling. So in today's episode I'll explain what these terms mean and how they may impact your work.

Links mentioned in the episode:

Ep 11Oct 9, 202331 min
Model diagnostics and selection (Ep. 11)
This episode is a discussion on model evaluation and selection. I discussed diagnostic plots using predictions and residuals. I covered approaches for model selection and factors to consider. The…
Ep 44Apr 21, 202526 min
Different estimation methods used in modeling (Ep. 44)
In this episode I discuss different algorithms used for pharmacometrics modeling. I describe difference between maximum likelihood and expectation maximization methods. I review the FO and FOCEI…
Ep 36Oct 28, 202427 min
Covariate Search Methods (Ep. 36)
This episode is a discussion of covariate search methods. I give definitions of covariates and predictors, and then I describe 3 different covariate search methods. For each method I describe the…

Never miss an episode

All episodes are free. Listen on your favorite platform.

61: Inter-occasion variability and shrinkage in PK modeling (Ep. 61)

Related episodes

Model diagnostics and selection (Ep. 11)

Different estimation methods used in modeling (Ep. 44)

Covariate Search Methods (Ep. 36)

Never miss an episode