Episode 36 · October 28, 2024 · 27 min

36: Covariate Search Methods (Ep. 36)

Speed

This episode is a discussion of covariate search methods. I give definitions of covariates and predictors, and then I describe 3 different covariate search methods. For each method I describe the pros and cons associated with each one, including bias and time limitations.

Links discussed in the show:

Evaluation of the Boruta method for covariate selection
You can connect with me on LinkedIn and send me a message
Send me a message
Sign up for my newsletter

Ep 44Apr 21, 202526 min
Different estimation methods used in modeling (Ep. 44)
In this episode I discuss different algorithms used for pharmacometrics modeling. I describe difference between maximum likelihood and expectation maximization methods. I review the FO and FOCEI…
Ep 61Oct 26, 202623 min
Inter-occasion variability and shrinkage in PK modeling (Ep. 61)
Today’s episode is about inter-occasion variability and η-shrinkage. Episodes 11, 36, 44, and 45 covered diagnostics, covariate search, estimation methods, and base-model selection. None of them…
Ep 37Nov 11, 202417 min
Dose Proportionality (Ep. 37)
In this episode I talk about dose proportionality, which is a surrogate for determining if we have linear clearance across a range of dose levels. I discuss 3 different methods that people use to…

Never miss an episode

All episodes are free. Listen on your favorite platform.

36: Covariate Search Methods (Ep. 36)

Related episodes

Different estimation methods used in modeling (Ep. 44)

Inter-occasion variability and shrinkage in PK modeling (Ep. 61)

Dose Proportionality (Ep. 37)

Never miss an episode