Episode 20 · February 26, 2024 · 16 min

20: Tackling TMDD Models (Ep. 20)

Speed

Today’s show is about TMDD or target-mediated drug disposition models. I review the scientific and physiologic basis for TMDD models, how to review data and determine if a TMDD model is needed. I review the various modeling approaches along with my recommendations for specific TMDD models. I hope this information helps you understand how to recognize TMDD behaviors and the options for modeling that data.

Links discussed in the show:

Ep 59Aug 24, 202629 min
Renal and Hepatic Impairment (Ep. 59)
Today’s episode is a discussion of renal and hepatic impairment. I review the biology of the kidney and liver and how we analyze pharmacokinetic data to assess their impact on drug exposure. Links…
Ep 24Apr 22, 202424 min
Choosing an absorption model (Ep. 24)
Today’s show discussed approaches for modeling absorption profiles. I discussed the rationale behind modeling absorption and then described some common models. These included first-order absorption,…
Ep 15Dec 11, 202326 min
QSP, PBPK, PKPD, PopPK … analysis abbreviation soup! (Ep. 15)
In today’s episode I cover 4 different modeling approaches: QSP, PBPK, PopPK, and PKPD. All of these are methods for analyzing data to predict either drug concentrations, or a response variable. But…

Never miss an episode

All episodes are free. Listen on your favorite platform.

20: Tackling TMDD Models (Ep. 20)

Related episodes

Renal and Hepatic Impairment (Ep. 59)

Choosing an absorption model (Ep. 24)

QSP, PBPK, PKPD, PopPK … analysis abbreviation soup! (Ep. 15)

Never miss an episode