In this episode I discuss different algorithms used for pharmacometrics modeling. I describe difference between maximum likelihood and expectation maximization methods. I review the FO and FOCEI maximum likelihood algorithms. I then review SAEM, IMP, and QRPEM expectation maximization algorithms that are available. I conclude with an brief explanation of the difference between parameter estimation and parameter uncertainty.

Links discussed in the show:

• PMXRepo
• James Ousey LinkedIn page
• Manuscript by Liu and Wang, 2016
• You can connect with me on LinkedIn and send me a message
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